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• Time of issue:2018-02-26 14:27
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(Summary description)(a) Stereoisomerism, conformational relationship, metabolism of vitamin A in the body, and the name of the precursor drug (vitamin A prodrug)

　　1. Stereoisomerism

　　2. conformational relationships

　　Growing or shortening the fatty chain and increasing the double bond of cyclohexene both reduce the biological activity, and the four double bonds on the side chain must be conjugated to the double bond of cyclohexene, otherwise the activity is lost. The four double bonds in the side chain must be conjugated to the double bonds of cyclohexene, otherwise the activity is lost.

　　3. In vivo metabolism

　　It can be oxidized by dehydrogenase in the body, and the first step of the metabolism product with the same activity as vitamin A is retinal, then it can be oxidized by dehydrogenase to produce retinoic acid, that is, vitamin A acid (retinoic acid), which can prevent the synthesis of nitrosamines in the body, and has the effect of preventing early cancer.

　　4. The name of the precursor drug (vitamin A original) β-carotene, zeaxanthin.

　　(B) The structure and characteristics, physicochemical properties and main uses of vitamin A, D3, E and K3
　　(C) The metabolism of vitamin D in the body and the characteristics of metabolites

　　7-dehydrocholestrol is transformed into vitamin D3 by ultraviolet radiation, and ergocalciferol is transformed into vitamin D2 by ultraviolet radiation. vitamin D2 and D3 are metabolized into the more biologically active 1α,25-dihydroxyvitamin D2 and D3 after two hydroxylations in the liver and kidney before they have the effect of promoting the absorption of calcium and phosphorus in the intestine and helping bone calcification.