Industry News_Industry News_Suzhou Soken Chemical Co., Ltd

February chemiwholly production increased by 21.08% year-on-year

2015-01-27

　　Sinochem News February chemical fiber production enterprises for 788 units, the production of 228,540.97 tons, the cumulative output of 486,3582.52 tons, an increase of 21.08% this month, the cumulative year-on-year growth of 18.24%. (More related information: 010-82032707) 　　"2014 Petroleum and Chemical Wastewater Treatment New Technology Development Forum" was held in Shanghai on May 20 　　Organized by China Chemical News, industry enterprises can register to attend for free! 　　For details, please contact: 010-82039210

2011 Pharmacist Practice Exam - Medicinal Chemistry Fat Soluble Vitamins

2018-02-27

　　(a) Stereoisomerism, conformational relationship, metabolism of vitamin A in the body, and the name of the precursor drug (vitamin A prodrug) 　　1. Stereoisomerism 　　2. conformational relationships 　　Growing or shortening the fatty chain and increasing the double bond of cyclohexene both reduce the biological activity, and the four double bonds on the side chain must be conjugated to the double bond of cyclohexene, otherwise the activity is lost. The four double bonds in the side chain must be conjugated to the double bonds of cyclohexene, otherwise the activity is lost. 　　3. In vivo metabolism 　　It can be oxidized by dehydrogenase in the body, and the first step of the metabolism product with the same activity as vitamin A is retinal, then it can be oxidized by dehydrogenase to produce retinoic acid, that is, vitamin A acid (retinoic acid), which can prevent the synthesis of nitrosamines in the body, and has the effect of preventing early cancer. 　　4. The name of the precursor drug (vitamin A original) β-carotene, zeaxanthin. 　　(B) The structure and characteristics, physicochemical properties and main uses of vitamin A, D3, E and K3 　　(C) The metabolism of vitamin D in the body and the characteristics of metabolites 　　7-dehydrocholestrol is transformed into vitamin D3 by ultraviolet radiation, and ergocalciferol is transformed into vitamin D2 by ultraviolet radiation. vitamin D2 and D3 are metabolized into the more biologically active 1α,25-dihydroxyvitamin D2 and D3 after two hydroxylations in the liver and kidney before they have the effect of promoting the absorption of calcium and phosphorus in the intestine and helping bone calcification.

2011 Pharmacist Practice Exam - Pharmaceutical Chemistry Other Antibiotics

2018-02-27

　　(A) Chloramphenicol action and adverse reactions, stability 　　Chloramphenicol is a broad-spectrum antibiotic, the main disadvantages are high toxicity, inhibition of the bone marrow hematopoietic system, causing aplastic anemia, so the clinical application is limited. However, it is still one of the preferred drugs in controlling typhoid and typhus. Its aqueous solution is prone to hydrolysis reaction of amide in the range of pH2-7, and the degradation speed is accelerated with the increase of temperature. 　　(B) The main pharmacological effects of peptide antibiotics polymyxin and cyclosporine A 　　(C) The effect of lincomycin 　　Lincomycin, which is effective against gram-positive bacteria and has strong penetration to tissues, is therefore suitable for osteomyelitis. It is also used to treat staphylococci, hemolytic streptococci, pneumococci causing skin and soft tissue infections, upper and lower respiratory tract infections, etc.

Experts recommend the latest top seven biochemistry papers

2018-02-26

Biolink reports that the "Faculty of 1000 Medicine", also known as the "Faculty of 1000 Medicine", is an international authority composed of 2,500 of the world's top medical professors, including those from Harvard University and Cambridge University in the United Kingdom. Seven of the most popular recent biochemistry papers are as follows. Answer the simple questionnaire and get the 4th edition of Roche's technical guide for free. Click to get it now! L.Q. Chen et al. "Sugar transporters for intercellular exchange and nutrition of pathogens," Nature, 468:527-32, 2010. Evaluations by Julian Schroeder, UCSD; Akiko Sugio and Saskia Hogenhout, The John Innes Centre, UK; John Patrick, Univ Newcastle, Australia; David Alpers, Wash U Sch of Med; Bruno Stieger, Univ Hosp Zurich; Tapio Palva, Univ Helsinki; H Ekkehard Neuhaus, Univ Kaiserslautern, Germany. free F1000 Evaluation A previously unknown group of sugar transport proteins has been identified - initially in plants, but due to the apparently widespread distribution of homologous proteins, they have also been identified in animals. In plants, these SWEET receptors correspond to those transport proteins that have long been sought to supply glucose to nectar, seeds and pollen development. Some of these transport proteins are used by pathogens to supply sugars for replication. Postnatal homologous proteins also regulate glucose transport and may also be involved in sugar efflux from the small intestine, liver, epididymis, and mammary cells. M.M. Reddy, et al. "Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening," Cell Evaluated by Angela Vincent, Univ of Oxford, UK; Robert Powers, Univ of Nebraska; Soumitra Ghosh and Kavita Shah, Purdue Univ; Ivan Gerling, Univ Tennessee Health Sci Cen; David Holtzman, Wash Univ School of Med. Free F1000 Evaluation Scientists in the United States may have discovered a new way to use blood tests to search for clues to Alzheimer's disease; this discovery, if proven, could be extended to other diseases. If this works for Alzheimer's disease, it shows that this is a fairly universal platform that could work for many different diseases," said Thomas Kodadek of the Scripps ResearchInstitute. Kodadek noted, "Now we need to put this approach in the hands of disease experts and deal with diseases where early diagnosis and detection are key to treatment." Alzheimer's disease is the most common form of dementia and is currently untreatable. 5 million people in the U.S. suffer from this disease, so there are many people who may not see much use for this disease detection method. But the pharmaceutical industry may use this information to more accurately identify patients undergoing clinical trials. Kodadek tried a new method of identifying disease signals in the blood, using molecules called peptoids to detect antibodies in the bloodstream of animals and patients suffering from specific diseases. After isolating more immunoglobulins (Immunoglobulin, a major antibody type) from rats with a physical condition similar to multiple sclerosis (multiplesclerosis) than healthy rats, he transferred the subjects to humans, testing six Alzheimer's patients, six Parkinson's disease patients, and six healthy people. These tests found that three molecules captured three times as much immunoglobulin in Alzheimer's patients as in healthy individuals with Parkinson's or controls. A.P. Carter et al. "Crystal structure of the dynein motor domain," Science, 331:1159-65, 2011. evaluated by Terrence Frey, San Diego State Univ.; Linda Amos, MRC Lab of Molecular Bio, UK; Giampietro Schiavo, Imperial Cancer Research Fund, UK; Sharyn Endow, Duke Univ. Medical Center; Peter Stathopulos and Mitsuhiko Ikura, Ontario Cancer Inst, Canada. Free F1000 Evaluation The first crystal structure of dynein, the largest cellular scaffold kinetic protein, was obtained, providing some clues to the data on the "travel" of this giant protein along microtubules. G. Xu et al. "Crystal structure of inhibitor of kappaB kinase beta," Nature, doi:10.1038/nature09853, 2011. evaluated by Andrew Beenken and Moosa Mohammadi, NYU Langonne Medical Center; John Kyriakis, Tufts Medical Center. free F1000 Evaluation In this article researchers reveal for the first time the crystal structure of a kinase inhibitor, KB kinase inhibitor, that plays an important role in inflammation, immunity and apoptosis. The researchers found that its structure is very similar to that of scissors. The new findings may help scientists to develop anti-inflammatory drugs that target this kinase. M.A. Fisher et al. "De novo designed proteins from a library of artificial sequences function in Escherichia coli and enable cell Evaluated by Etienne Joly, CNRS, France; Donald Doyle, Georgia Inst of Technology; Ulrich Muller. Muller. Free F1000 Evaluation Scientists in the United States claim to have used artificial genes for the first time to synthesize artificial proteins t

Pharmacist Practice Exam - Pharmaceutical Chemistry Fat Soluble Vitamins

2018-02-26

(a) Stereoisomerism, conformational relationship, metabolism of vitamin A in the body, and the name of the precursor drug (vitamin A prodrug) 　　1. Stereoisomerism 　　2. conformational relationships 　　Growing or shortening the fatty chain and increasing the double bond of cyclohexene both reduce the biological activity, and the four double bonds on the side chain must be conjugated to the double bond of cyclohexene, otherwise the activity is lost. The four double bonds in the side chain must be conjugated to the double bonds of cyclohexene, otherwise the activity is lost. 　　3. In vivo metabolism 　　It can be oxidized by dehydrogenase in the body, and the first step of the metabolism product with the same activity as vitamin A is retinal, then it can be oxidized by dehydrogenase to produce retinoic acid, that is, vitamin A acid (retinoic acid), which can prevent the synthesis of nitrosamines in the body, and has the effect of preventing early cancer. 　　4. The name of the precursor drug (vitamin A original) β-carotene, zeaxanthin. 　　(B) The structure and characteristics, physicochemical properties and main uses of vitamin A, D3, E and K3 　　(C) The metabolism of vitamin D in the body and the characteristics of metabolites 　　7-dehydrocholestrol is transformed into vitamin D3 by ultraviolet radiation, and ergocalciferol is transformed into vitamin D2 by ultraviolet radiation. vitamin D2 and D3 are metabolized into the more biologically active 1α,25-dihydroxyvitamin D2 and D3 after two hydroxylations in the liver and kidney before they have the effect of promoting the absorption of calcium and phosphorus in the intestine and helping bone calcification.

Shanghai Auto Show: Dow Chemical exhibits innovative materials for the automotive industry

2018-02-26

Shanghai, April 18, 2011 -- Dow Automotive Systems today unveiled a series of innovations and future growth plans to enhance local market performance during the Shanghai International Auto Show, reinforcing the company's position as a leading supplier of material solutions to the automotive industry. Dow Automotive Systems' innovation efforts are focused on four core areas: automotive lightweighting, safety, emissions control, and improving vehicle quality and appeal. "We believe these four areas are key points of development for the automotive industry, which has been concluded to meet the needs of consumers and to address the challenges facing the automotive industry. Our development goal is to bring real value to our customers," explained Steven Henderson, president of Dow's Automotive Systems business unit. A series of innovations presented by Dow Chemical during the auto show include. -Automotive lightweighting solutions: Two-component polyurethane bonding systems can bond materials with different properties, which can help automobiles use more lightweight materials, such as aluminum and composites. This technology has been commercially available since 2009 in some major European car manufacturers and was launched in China in early 2011. In addition, since 2010, Dow has also introduced its epoxy and polyurethane composites to the Asian market to replace metals and other composites in the design of automotive interiors and exteriors. -Safety: BETAMATE™ FLEX structural adhesive is the latest development that effectively balances mechanical properties and flexibility to address the thermal deformation that can occur after curing of aluminum and other lightweight metal parts. In addition, Dow introduced BETAWIPE™ Hydro Glass Adhesive System, the world's first one-component, water-activated technology for automotive glass bonding that is free of volatile organic compounds (VOCs). This technology can effectively improve the working environment for automotive manufacturing workers. -Improving the quality and appeal of automobiles: AUTOTHANE™ high-performance microporous polyurethane material systems to help automotive OEMs and Tier 1 suppliers address suspension vibration control issues. In addition to its existing product line, Dow has integrated a range of rubber-to-metal adhesive products - including MEGUM™, THIXON™ and ROBOND™ adhesives - to meet the need to bond elastomers to metals, engineering plastics and other types of elastomers under varying conditions. Exhaust emission control: AERIFY™ diesel particulate filters help automakers achieve emissions control. These filters offer low back pressure to enhance engine efficiency, smaller size to improve packaging efficiency, and superior durability with outstanding dust and chemical resistance. In addition to its ongoing investment in R&D and innovation efforts, Dow Automotive Systems continues to invest to better serve the needs of its Asian customers. The company has just announced its new propylene oxide (PO) and elastomer manufacturing plant in Thailand, both of which will be in production in 2011. Dow has also strengthened its local R&D and technical service capabilities by adding technical teams and purchasing world-class equipment. "These are just some of the actions we are taking to optimize our services to better serve our customers in Asia. I am confident that you will see more local automotive manufacturers on our customer list. We will also continue our efforts to combine our local knowledge with our global experience to better serve our customers," added Mr. Han De Shen.

Bedford Bullish on Wingate International and Monsanto as Grain Demand Increases

2018-02-26

(iNewswire) April 18, 2012 - The Bedford Report recently released an analysis of the global crop outlook, which includes Wingate International and Monsanto Company. In the report, Bedford Report said that as the middle class grows in developing countries with large populations, such as Brazil, India and China, the demand for quality food will also increase. Companies in the agrochemical industry are expected to benefit as farmers take advantage of higher crop prices by planting more corn and smaller crops and choosing the best fertilizer products, and are expected to see their revenues soar this spring. Earlier this year in April, Monsanto said that they benefited from higher corn seed prices, their second quarter profits rose 15% year-on-year, with sales of their premium brand corn increasing relatively more in Brazil, the U.S. and Europe, and sales in the agricultural production division increasing 10%. The company also said that their cotton business performed well this year. Sales for the first three months of the year (ending March 31, 2011) more than doubled to $50.2 million, thanks to increased demand for the company's products in traditional markets and increased performance in several new markets, according to Wing Yip International. The Bedford Report's research on Wingate International and Monsanto can be found at www.bedfordreport.com/2011-04-YONG www.bedfordreport.com/2011-04-MON (iShares) April 18, 2012 - Bedford Report recently issued a report on the global crop outlook, covering both Everest International and Monsanto Co. In the report, Bedford Report said that as the middle class grows in developing countries with large populations, such as Brazil, India and China, the demand for quality food will also increase. Companies in the agrochemical industry are expected to benefit as farmers take advantage of higher crop prices by planting more corn and smaller crops and choosing the best fertilizer products, and are expected to see their revenues soar this spring. Earlier this year in April, Monsanto said that they benefited from higher corn seed prices, their second quarter profits rose 15% year-on-year, with sales of their premium brand corn increasing relatively more in Brazil, the U.S. and Europe, and sales in the agricultural production division increasing 10%. The company also said that their cotton business performed well this year. Sales for the first three months of the year (ending March 31, 2011) more than doubled to $50.2 million, thanks to increased demand for the company's products in traditional markets and increased performance in several new markets, according to Wing Yip International. The Bedford Report's research on Wingate International and Monsanto can be found at www.bedfordreport.com/2011-04-YONG www.bedfordreport.com/2011-04-MON

Pharmacist Practice Exam - Pharmaceutical Chemistry Other Antibiotics

2018-02-26

(A) Chloramphenicol action and adverse reactions, stability 　　Chloramphenicol is a broad-spectrum antibiotic, the main disadvantages are high toxicity, inhibition of the bone marrow hematopoietic system, causing aplastic anemia, so the clinical application is limited. However, it is still one of the preferred drugs in controlling typhoid and typhus. Its aqueous solution is prone to hydrolysis reaction of amide in the range of pH2-7, and the degradation speed is accelerated with the increase of temperature. (B) The main pharmacological effects of peptide antibiotics polymyxin and cyclosporine A (C) The effect of lincomycin 　　Lincomycin, which is effective against gram-positive bacteria and has strong penetration to tissues, is therefore suitable for osteomyelitis. It is also used to treat staphylococci, hemolytic streptococci, pneumococci causing skin and soft tissue infections, upper and lower respiratory tract infections, etc.

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